Research
Research in the Integrated Catalysis CDT is based on the integration of biocatalytic and chemocatalytic processes.
The integration of these processes is fundamental to the future of molecule manufacturing across the entire chemical industry.
Research conducted within iCAT will see us collaborating closely with the Manchester Institute of Biotechnology and the Centre of Excellence for Biocatalysis, Biotransformation and Biocatalytic Manufacture (CoEBio3).
iCAT research projects connect the disciplines of chemocatalysis, chemical engineering and biocatalysis in creative ways to solve problems in molecule making.
Publications from iCAT CDT Postgraduate Researchers
Most recent on publication on top. Please note that the author named below is the iCAT CDT student, not necessarily the lead author for the publication.
- Romain Jamagne et. al., Macroscopic Spiral Rotation of Microscopic Objects Induced by Nanoscale Rotaxane Dynamics. Chem, 2024, 10, 1-11. https://doi.org/10.1016/j.chempr.2024.03.013
- Aife Conboy et. al., Synthesis of Benzenes from Pyridines via N to C Switch. Chem, 2024, 10, 1940-1949. https://doi.org/10.1016/j.chempr.2024.05.004
- Ewan Moody et. al., Modern Approaches to Therapeutic Oligonucleotide Manufacturing. Science, 2024, 384, p.eadl4015. https://doi.org/10.1126/science.adl4015
- Emma Pye et. al, Alkyl Cyclopropyl Ketones in Catalytic Formal [3 + 2] Cycloadditions: The Role of SmI2 Catalyst Stabilization. J. Am. Chem. Soc., 2024, 146, 12799-12807. https://doi.org/10.1021/jacs.4c03073
- Valentina Cuomo et al., Aryl Sulfonium Salt Electron Donor-acceptor Complexes for Halogen Atom Transfer: Isocyanides as Tunable Coupling Partners. Chem, 2024, 10, 1240-1251. https://doi.org/10.1016/j.chempr.2024.01.020
- Alexander Betts et. al., Endergonic Synthesis Driven by Chemical Fuelling. Nat. Synth., 2024, 3, 707-714. https://doi.org/10.1038/s44160-024-00493-w
- Jake Foster, Thomas Lister et. al., A Non-canonical Nucleophile Unlocks a New Mechanistic Pathway in a Designed Enzyme. Nat. Commun., 2024, 15, 1956. https://doi.org/10.1038/s41467-024-46123-z
- Robbie Clark et. al., Depolymerization within a Circular Plastics System. Chem. Rev., 2024, 124, 2617–2650. https://doi.org/10.1021/acs.chemrev.3c0073
- Jake Foster et. al., An Efficient Pyrrolysyl-tRNA Synthetase for Economical Production of MeHis Containing Enzymes. Faraday Discus., 2024. https://doi.org/10.1039/D4FD00019F
- Jacob Kenyon et al., Electrochemical Ruthenium-Catalysed Directed C-H Functionalization of Arenes with Boron Reagents. Adv. Synth. Catal. 2023. https://doi.org/10.1002/adsc.202301184
- Anastasios Charitou et al., Aryne-Enabled C−N Arylation of Anilines. Angew. Chem. Int. Ed. 2023, e202310583. https://doi.org/10.1002/anie.202310583
- Alice Ieong et al., Furan Release via Force-Promoted Retro-[4+2][3+2] Cycloaddition. J. Am. Chem. Soc. 2023, 145, 38, 20782–20785. https://doi.org/10.1021/jacs.3c08771
- John Davidson, Jake Foster et. al., Engineering Enzymes for Environmental Sustainability, Angew. Chem. Int. Ed., 2023, 62, e202309305. https://doi.org/10.1002/anie.202309305
- Alfie Taylor et al., An NHC-Catalyzed Desulfonylative Smiles Rearrangement of Pyrrole and Indole Carboxaldehydes. J. Org. Chem. 2023, 88, 12821-12825. https://doi.org/10.1021/acs.joc.3c01089
- Thomas Lister et al., Transition-Metal-Catalyzed C–H Bond Activation for the Formation of C–C Bonds in Complex Molecules. Chem. Rev. 2023, 123, 7692–7760. https://doi.org/10.1021/acs.chemrev.2c00888
- Lewis Caiger et al., The Merger of Aryl Radical-Mediated Halogen-Atom Transfer (XAT) and Copper Catalysis for the Modular Cross-Coupling-Type Functionalization of Alkyl Iodides. ACS Catal. 2023, 13, 4985–4991. https://doi.org/10.1021/acscatal.3c00571
- Thomas Lister et al., Engineered Biocatalysts for Enantioselective Reductive Aminations of Cyclic Secondary Amines. ChemCatChem, 2023. 15, e202300256. https://doi.org/10.1002/cctc.202300256
- Emma Pye et. al., A Catalytic Alkene Insertion Approach to Bicyclo[2.1.1]hexane Bioisosteres. Nat. Chem., 2023, 15, 535-541. https://doi.org/10.1038/s41557-023-01135-y
- William Jobbins et al., Reactivity of Tetrel Functionalized Heptapnictogen Clusters towards Heteroallenes. Dalton Trans., 2023, 52, 2384-2391. https://doi.org/10.1039/D2DT04074C
- Alexander Betts et al., Bimetallic Aluminium- and Niobium-Doped MCM41 for Efficient Conversion of Biomass-Derived 2-Mehyltetrahydrofuran to Pentadienes, Angewandte Chemie, 2022, 61, e202212164. https://doi.org/10.1002/anie.202212164
- Romain Jamagne et al., A Tape-reading Molecular Ratchet, Nature, 2022, 612, 78-82. https://doi.org/10.1038/s41586-022-05305-9
- Jonathan Trimble et al., A Designed Photoenzyme for Enantioselective [2+2] Cycloadditions, Nature, 2022, 611, 709-714. https://doi.org/10.1038/s41586-022-05335-3
- Jake Foster et al., Directed Evolution of an Efficient and Thermostable PET Depolymerase, Nature Catalysis, 2022, 5, 673-681. https://doi.org/10.1038/s41929-022-00821-3
- Emma Pye et al., Diastereoselective Radical 1,4-Ester Migration: Radical Cyclizations of Acyclic Esters with SmI2, J. Am. Chem. Soc., 2022, 144, 13946-
13952. https://doi.org/10.1021/jacs.2c05972 - Stanley Sowerby Thomas et al., Merging Enzymes with Chemocatalysis for Amide Bond Synthesis, Nat. Commun., 2021,13, 380. https://doi.org/10.1038/s41467-022-28005-4
- Romain Jamagne et al., α-Amino-iso-Butyric Acid Foldamers Terminated with Rhodium(I) N-Heterocyclic Carbene Catalysts, Chem Eur J, 2021, 28, e202104293. https://doi.org/10.1002/chem.202104293
- Lewis Caiger et al., Radical Hydroxymethylation of Alkyl I odides using Formaldehyde as a C1 Synthoy, Chemical Science, 2021, 12, 10448-10454. https://doi.org/10.1039/D1SC03083C
- Emma Pye et al., Recent Advances in the Chemistry of Ketyl Radicals, Chem. Soc. Rev. 2021, 50, 5349-5365. https://doi.org/10.1039/D0CS00358A